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NFL picks, predictions for Week 1: Rams fend off Bills to begin Super Bowl defense; Raiders, Browns earn upsets

  • Thread starter Thread starter Bill Bender
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Bill Bender

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In our picks and predictions for Week 1 of the 2022 NFL season, Los Angeles begins the defense of its Super Bowl title by beating back Buffalo while Las Vegas upsets another title contender and Baker Mayfield loses his revenge game.
 
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